After years of preparation and beta-phase, finally, Wine has been able to reach launch as Wine 1.0. Why is it significant? Because this is the software package designed to be able to run many Windows applications from a GNU/Linux distribution. If you want to switch to Linux, you may not be willing to abandon some of the applications that were developped for Windows.
Wine is there to solve the problem. It runs many games and it runs Photoshop CS2 and CS3 from the box (I did not test it myself, though). It was the plain objective of Google when they allocated money and developers to support this project. They reached their goal.
It is probably the right time to try OpenSuse 11.0 (one of the best new Linux distributions) with Wine.
See also: Run Windows Apps in Linux with Wine 1.0.